Pulmonary surfactant: functions and molecular composition
نویسندگان
چکیده
منابع مشابه
Pulmonary surfactant: functions and molecular composition.
This review briefly notes recent findings important for understanding the surface mechanical functions of pulmonary surfactant. Currently known surfactant-specific proteins and lipids are discussed, with an eye to their possible functions. Competing models of the alveolar subphase life cycle of surfactant are also presented. It is concluded that, in spite of much effort, we still do not underst...
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Surfactant proteins A (SP-A) and D (SP-D) are established as essential components of our innate immune system for protecting the lung from pathogens and allergens. They essentially exert their protective functions by regulating pulmonary homeostasis. Both proteins are however widely expressed throughout the body, including the female reproductive tract, urinary tract, gastrointestinal tract, th...
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Pulmonary surfactant is a complex mixture of lipids and proteins that, by modulating surface tension during breathing, prevents alveolar collapse at exhalation and overdistention at inspiration. Surfactant is synthesized by type II pneumocytes, assembled in lamellar bodies and secreted at the air-liquid interface of the alveolus. This surface-active material is re-uptaken by alveolar type II ce...
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STUDY OBJECTIVES To determine whether chronic lung inflammation in young adult patients with cystic fibrosis (CF) alters the composition and function of surfactant and surfactant components in bronchoalveolar secretions. DESIGN A prospective, descriptive study. SETTING An adult CF center in a tertiary health-care center. PARTICIPANTS Thirteen normal volunteer (NV) subjects recruited via l...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 1998
ISSN: 0925-4439
DOI: 10.1016/s0925-4439(98)00060-x